Nature Communications (May 2021)
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis
- Michio Sato,
- Tsuyoshi Kadomatsu,
- Keishi Miyata,
- Junco S. Warren,
- Zhe Tian,
- Shunshun Zhu,
- Haruki Horiguchi,
- Aman Makaju,
- Anna Bakhtina,
- Jun Morinaga,
- Taichi Sugizaki,
- Kaname Hirashima,
- Kumiko Yoshinobu,
- Mai Imasaka,
- Masatake Araki,
- Yoshihiro Komohara,
- Tomohiko Wakayama,
- Shinichi Nakagawa,
- Sarah Franklin,
- Koichi Node,
- Kimi Araki,
- Yuichi Oike
Affiliations
- Michio Sato
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Tsuyoshi Kadomatsu
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Keishi Miyata
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Junco S. Warren
- Division of Kumamoto Mouse Clinic (KMC), Institute of Resource Developmental and Analysis (IRDA), Kumamoto University
- Zhe Tian
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Shunshun Zhu
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Haruki Horiguchi
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Aman Makaju
- Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah
- Anna Bakhtina
- Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah
- Jun Morinaga
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Taichi Sugizaki
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Kaname Hirashima
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- Kumiko Yoshinobu
- Division of Bioinformatics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University
- Mai Imasaka
- Division of Developmental Genetics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University
- Masatake Araki
- Division of Bioinformatics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University
- Yoshihiro Komohara
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
- Tomohiko Wakayama
- Department of Histology, Graduate School of Medical Sciences, Kumamoto University
- Shinichi Nakagawa
- RNA Biology Laboratory, Faculty of Pharmaceutical Sciences, Hokkaido University
- Sarah Franklin
- Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah
- Koichi Node
- Department of Cardiovascular Medicine, School of Medicine, Saga University
- Kimi Araki
- Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University
- Yuichi Oike
- Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
- DOI
- https://doi.org/10.1038/s41467-021-22735-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardiomyocyte function due to inactivation of the DNA damage response and activation of mitochondrial bioenergetics.
