Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Yan Tang; David J. Kwiatkowski; Elizabeth P. Henske

doi:10.1038/s41467-022-32673-7

Nature Communications (Aug 2022)

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Yan Tang,
David J. Kwiatkowski,
Elizabeth P. Henske

Affiliations

Yan Tang: Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School
David J. Kwiatkowski: Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School
Elizabeth P. Henske: Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-022-32673-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 22

Abstract

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The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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