Simeprevir Potently Suppresses SARS-CoV‑2 Replication and Synergizes with Remdesivir

• Ho Sing Lo,
• Kenrie Pui Yan Hui,
• Hei-Ming Lai,
• Xu He,
• Khadija Shahed Khan,
• Simranjeet Kaur,
• Junzhe Huang,
• Zhongqi Li,
• Anthony K. N. Chan,
• Hayley Hei-Yin Cheung,
• Ka-Chun Ng,
• John Chi Wang Ho,
• Yu Wai Chen,
• Bowen Ma,
• Peter Man-Hin Cheung,
• Donghyuk Shin,
• Kaidao Wang,
• Meng-Hsuan Lee,
• Barbara Selisko,
• Cecilia Eydoux,
• Jean-Claude Guillemot,
• Bruno Canard,
• Kuen-Phon Wu,
• Po-Huang Liang,
• Ivan Dikic,
• Zhong Zuo,
• Francis K. L. Chan,
• David S. C. Hui,
• Vincent C. T. Mok,
• Kam-Bo Wong,
• Chris Ka Pun Mok,
• Ho Ko,
• Wei Shen Aik,
• Michael Chi Wai Chan,
• Wai-Lung Ng

Affiliations

Ho Sing Lo

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Kenrie Pui Yan Hui

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

Hei-Ming Lai

Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Xu He

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Khadija Shahed Khan

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Simranjeet Kaur

Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Junzhe Huang

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Zhongqi Li

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Anthony K. N. Chan

Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California, United States

Hayley Hei-Yin Cheung

School of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong

Ka-Chun Ng

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

John Chi Wang Ho

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

Yu Wai Chen

Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Hong Kong

Bowen Ma

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Peter Man-Hin Cheung

School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Donghyuk Shin

Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt am Main, Germany

Kaidao Wang

Protein Production Department, GenScript Biotech Corporation, Nanjing, Jiangsu Province, China

Meng-Hsuan Lee

Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

Barbara Selisko

Laboratoire d’Architecture et Fonction des Macromolécules Biologiques (AFMB), Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France

Cecilia Eydoux

Laboratoire d’Architecture et Fonction des Macromolécules Biologiques (AFMB), Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France

Jean-Claude Guillemot

Laboratoire d’Architecture et Fonction des Macromolécules Biologiques (AFMB), Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France

Bruno Canard

Laboratoire d’Architecture et Fonction des Macromolécules Biologiques (AFMB), Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France

Kuen-Phon Wu

Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

Po-Huang Liang

Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

Ivan Dikic

Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt am Main, Germany

Zhong Zuo

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Francis K. L. Chan

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

David S. C. Hui

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Vincent C. T. Mok

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Kam-Bo Wong

School of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong

Chris Ka Pun Mok

HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Shatin, Hong Kong

Ho Ko

Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

Wei Shen Aik

Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Michael Chi Wai Chan

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

Wai-Lung Ng

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong