Journal of Inflammation Research (Sep 2022)

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

  • Ma M,
  • Liu Y,
  • Wang L,
  • Yang R,
  • Li Z,
  • Gao S,
  • Li L,
  • Yu C

Journal volume & issue
Vol. Volume 15
pp. 5141 – 5156

Abstract

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Mei Ma,1,* Yijia Liu,1,* Lichun Wang,2,* Rongrong Yang,1 Zhu Li,1 Sheng Gao,3 Lin Li,1 Chunquan Yu1 1Department of Graduate Schools, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2Department of Information Center, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 3Department of Endocrine Metabolic Diseases, Nankai Hospital, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Li, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China, Email [email protected] Sheng Gao, Nankai Hospital, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin, People’s Republic of China, Email [email protected]: This study explored the relationship between monocyte-to-lymphocyte ratio (MLR) as well as other leukocyte-derived ratios and carotid plaques in patients with coronary heart disease (CHD).Patients and Methods: A total of 12,093 patients with CHD were selected as research participants. Leukocyte-derived ratios assessed in this study included neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), MLR, platelet-to-lymphocyte ratio (PLR), white blood cell-to-mean platelet volume ratio (WMR), lymphocyte×neutrophil/104 ratio (MNM), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI). Leukocyte-derived ratios were divided into four groups according to quarters. Logistic regression analysis was performed to evaluate the relationship between leukocyte-derived ratios and the incidence, number, and echo characteristics of carotid plaques in patients with CHD. Further analysis was performed after adjusting for confounding factors.Results: Among the 12,093 participants, 71.7% had carotid plaques. After adjusting for confounding factors, MLR, NLR, dNLR, PLR, SII, SIRI, and WMR were found to be associated with carotid plaque formation. Among them, MLR had the strongest association with the incidence of carotid plaques (odd ratio[OR]:1.889; 95% confidence interval[CI]:1.406– 2.539) and hyperechoic plaques (OR:2.024; 95% CI:1.481– 2.767). When MLR was viewed as a categorical variable, the risk of carotid plaque formation in Q4 was 1.4 times higher than that in Q1. The relationship between MLR and carotid plaques in females (OR:2.250; 95% CI:1.458– 3.473) was stronger than that in males (OR: 1.638; 95% CI:1.102–-2.436). The relationship between MLR and carotid plaques in patients younger than 65 years (OR:3.597; 95% CI:2.379– 5.439) was stronger than that in those older than 65 years (OR:1.577; 95% CI:1.046– 2.378).Conclusion: Leukocyte-derived ratios were related to the incidence, number, and echo characteristics of carotid plaques. In particular, MLR, an inflammatory biomarker that encompasses innate and adaptive immunity, may be of great value in revealing the incidence and echo characteristics of plaques.Graphical Abstract: Keywords: coronary heart disease, leukocyte-derived ratios, monocyte-to-lymphocyte ratio, carotid plaque

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