Nature Communications (Aug 2020)

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

  • Tadashi Yamamuro,
  • Tsuyoshi Kawabata,
  • Atsunori Fukuhara,
  • Shotaro Saita,
  • Shuhei Nakamura,
  • Hikari Takeshita,
  • Mari Fujiwara,
  • Yusuke Enokidani,
  • Gota Yoshida,
  • Keisuke Tabata,
  • Maho Hamasaki,
  • Akiko Kuma,
  • Koichi Yamamoto,
  • Iichiro Shimomura,
  • Tamotsu Yoshimori

DOI
https://doi.org/10.1038/s41467-020-17985-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads to adipocyte dysfunction via excess autophagic degradation of SRC-1 and TIF2.