A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

Abstract

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.

Keywords

• thiazole
• thiazoline
• manganese dioxide
• oxidation