PLoS ONE (Jan 2014)

Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

  • Junjie Zhang,
  • Xuewen Huang,
  • Juanjuan Xiao,
  • Yajun Yang,
  • Yinghui Zhou,
  • Xiaofeng Wang,
  • Qingmei Liu,
  • Jingmin Yang,
  • Mengyun Wang,
  • Lixin Qiu,
  • Yabiao Zheng,
  • Ping Zhang,
  • Jin Li,
  • Ya'nong Wang,
  • Qingyi Wei,
  • Li Jin,
  • Jiucun Wang,
  • Minghua Wang

DOI
https://doi.org/10.1371/journal.pone.0100055
Journal volume & issue
Vol. 9, no. 6
p. e100055

Abstract

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UNLABELLED:MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC:p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.