Pulmonary Circulation (Jul 2023)

Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model

  • Takayuki J. Sanada,
  • Koji Hosomi,
  • Jonguk Park,
  • Akira Naito,
  • Seiichiro Sakao,
  • Nobuhiro Tanabe,
  • Jun Kunisawa,
  • Koichiro Tatsumi,
  • Takuji Suzuki

DOI
https://doi.org/10.1002/pul2.12266
Journal volume & issue
Vol. 13, no. 3
pp. n/a – n/a

Abstract

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Abstract This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.

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