Frontiers in Pharmacology (Jan 2019)

A Guide to PIN1 Function and Mutations Across Cancers

  • Maguie El Boustani,
  • Maguie El Boustani,
  • Lucia De Stefano,
  • Lucia De Stefano,
  • Isabella Caligiuri,
  • Nayla Mouawad,
  • Nayla Mouawad,
  • Carlotta Granchi,
  • Vincenzo Canzonieri,
  • Tiziano Tuccinardi,
  • Antonio Giordano,
  • Flavio Rizzolio,
  • Flavio Rizzolio

DOI
https://doi.org/10.3389/fphar.2018.01477
Journal volume & issue
Vol. 9

Abstract

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PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues.

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