Natural Resistance Associated Macrophage Protein 1 Gene Polymorphism is Associated with Chronic Periodontitis Not Peri-Implantitis in an Iranian Population: A Cross Sectional Study

Abstract

In inflammatory diseases such as peri-implantitis (PI) and chronic periodontitis (CP) both adaptive and innate immunity play a part. Natural resistance associated macrophage protein 1 (NRAMP1) has considerable effects on macrophage function (phagocytosis) and host innate immune response against infections. The present study was to investigate the relationship of NRAMP1 gene polymorphisms with PI and CP in an Iranian population. In this cross sectional study 79 patients with CP, 38 patients with PI and 84 healthy controls presenting to the Periodontology Department of Shahid Beheshti University of Medical Sciences were enrolled. DNA was extracted from fresh blood samples of arm vein of participants and transferred to KBiosience institute (United Kingdom) for genotyping. X2 and Fisher’s exact tests were used by SPSS software v.19 for statistical analyzes. Significant differences were detected in the distribution of genotypes between control and CP groups both for rs17235409 and rs2276631 polymorphisms (P:0.044 and P:0.028 respectively). Distribution of genotypes differed insignificantly in comparison of PI and control groups for rs2276631 (P:0.623) and either rs17235409 (P:1) polymorphisms. Based on our results, we conclude that presence of G allele in both rs2276631 and rs17235409 location may be a protective factor against CP. More studies with a larger sample size in different populations are required for confirming NRAMP1 as a genetic determinant in periodontal disorders.

Keywords

• NRAMP1
• Periodontitis
• Peri-implantitis
• Polymorphism
• Inflammation
• Bone