OXIDATIVE STRESS IN LIVER FIBROGENESIS

Abstract

Oxidative stress has an important role in chronic liver diseases pathogenesis and liver fibrogenesis. Persistent and increased production of ROS (reactive oxygen species), induces the activation of hepatic stellate cells, by TGF-β, angiotensin II, PDGF and others pro-oxidant and pro-inflammatory cytokines mediated signals. The biggest liver fibrogenesis source of ROS are NOX1, NOX2 and NOX4, which determine HSC proliferation, migration, survival and also stimulation of hepatocyte apoptosis, activating multiple pathways. Hence, from initially fibrosis stages to liver cirrhosis, by supporting the excessive production of extracellular matrix compounds, oxidative stress is a determinant of liver fibrogenesis.

Keywords

• oxidative stress
• liver fibrogenesis
• ros