Synthesis and Characterization of Some New Bis-Chalconesand Their Transformation to Bis-Thiocarbamoyl-2- Pyrazoline Derivatives

Abstract

The starting materials alkoxy and benzyloxyacetophenones (1a-j, 2 and 3) have been prepared on the basis of Williamson synthesis of ether. The prepared and the available starting materials were reacted with terphthalaldehyde using green methods, Ultrasound , Microwave and solvent-free grinding method to give anew series of bis- chalcones (4a-s).The prepared bis- chalcones were subjected to react with thiosemicarbazide according to the Michael addition reaction to afford new biologically active bis-pyrazolinedeivatives(5a-s). The structure of the synthesized compounds were characterized by spectral methods: FT-IR, 1H-nmr, 13C-nmr andMass spectrometry.

Keywords

• Microwave
• Grinding
• Chalcone
• Thiosemicarbazide
• Pyrazoline