Nature Communications (Oct 2021)
SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques
- Ramon Roozendaal,
- Laura Solforosi,
- Daniel J. Stieh,
- Jan Serroyen,
- Roel Straetemans,
- Anna Dari,
- Muriel Boulton,
- Frank Wegmann,
- Sietske K. Rosendahl Huber,
- Joan E. M. van der Lubbe,
- Jenny Hendriks,
- Mathieu Le Gars,
- Liesbeth Dekking,
- Dominika N. Czapska-Casey,
- Nuria Guimera,
- Sarah Janssen,
- Sarah Tete,
- Abishek Chandrashekar,
- Noe B. Mercado,
- Jingyou Yu,
- Wouter Koudstaal,
- Juan J. Perez-Ruixo,
- Jerry Sadoff,
- Dan H. Barouch,
- Hanneke Schuitemaker,
- Roland Zahn
Affiliations
- Ramon Roozendaal
- Janssen Vaccines & Prevention B.V.
- Laura Solforosi
- Janssen Vaccines & Prevention B.V.
- Daniel J. Stieh
- Janssen Vaccines & Prevention B.V.
- Jan Serroyen
- Janssen Vaccines & Prevention B.V.
- Roel Straetemans
- Janssen R&D
- Anna Dari
- Janssen R&D
- Muriel Boulton
- Janssen R&D
- Frank Wegmann
- Janssen Vaccines & Prevention B.V.
- Sietske K. Rosendahl Huber
- Janssen Vaccines & Prevention B.V.
- Joan E. M. van der Lubbe
- Janssen Vaccines & Prevention B.V.
- Jenny Hendriks
- Janssen Vaccines & Prevention B.V.
- Mathieu Le Gars
- Janssen Vaccines & Prevention B.V.
- Liesbeth Dekking
- Janssen Vaccines & Prevention B.V.
- Dominika N. Czapska-Casey
- Janssen Vaccines & Prevention B.V.
- Nuria Guimera
- Janssen Vaccines & Prevention B.V.
- Sarah Janssen
- Janssen Vaccines & Prevention B.V.
- Sarah Tete
- Janssen Vaccines & Prevention B.V.
- Abishek Chandrashekar
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Noe B. Mercado
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Jingyou Yu
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Wouter Koudstaal
- Lucidity Biomedical Consulting
- Juan J. Perez-Ruixo
- Janssen R&D
- Jerry Sadoff
- Janssen Vaccines & Prevention B.V.
- Dan H. Barouch
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Hanneke Schuitemaker
- Janssen Vaccines & Prevention B.V.
- Roland Zahn
- Janssen Vaccines & Prevention B.V.
- DOI
- https://doi.org/10.1038/s41467-021-26117-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection observed 6 months post vaccination.
