Nature Communications (May 2021)
Single nucleus multi-omics regulatory landscape of the murine pituitary
- Frederique Ruf-Zamojski,
- Zidong Zhang,
- Michel Zamojski,
- Gregory R. Smith,
- Natalia Mendelev,
- Hanqing Liu,
- German Nudelman,
- Mika Moriwaki,
- Hanna Pincas,
- Rosa Gomez Castanon,
- Venugopalan D. Nair,
- Nitish Seenarine,
- Mary Anne S. Amper,
- Xiang Zhou,
- Luisina Ongaro,
- Chirine Toufaily,
- Gauthier Schang,
- Joseph R. Nery,
- Anna Bartlett,
- Andrew Aldridge,
- Nimisha Jain,
- Gwen V. Childs,
- Olga G. Troyanskaya,
- Joseph R. Ecker,
- Judith L. Turgeon,
- Corrine K. Welt,
- Daniel J. Bernard,
- Stuart C. Sealfon
Affiliations
- Frederique Ruf-Zamojski
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Zidong Zhang
- Lewis-Sigler Institute for Integrative Genomics, and Graduate Program in Quantitative and Computational Biology, Princeton University
- Michel Zamojski
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Gregory R. Smith
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Natalia Mendelev
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Hanqing Liu
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- German Nudelman
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Mika Moriwaki
- Division of Endocrinology and Metabolism, University of Utah
- Hanna Pincas
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Rosa Gomez Castanon
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- Venugopalan D. Nair
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Nitish Seenarine
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Mary Anne S. Amper
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Xiang Zhou
- Dept. of Pharmacology and Therapeutics, McGill University
- Luisina Ongaro
- Dept. of Pharmacology and Therapeutics, McGill University
- Chirine Toufaily
- Dept. of Pharmacology and Therapeutics, McGill University
- Gauthier Schang
- Dept. of Pharmacology and Therapeutics, McGill University
- Joseph R. Nery
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- Anna Bartlett
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- Andrew Aldridge
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- Nimisha Jain
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- Gwen V. Childs
- University of Arkansas for Medical Sciences
- Olga G. Troyanskaya
- Lewis-Sigler Institute for Integrative Genomics, and Graduate Program in Quantitative and Computational Biology, Princeton University
- Joseph R. Ecker
- Genomic Analysis Laboratory, The Salk Institute for Biological Studies
- Judith L. Turgeon
- Department of Internal Medicine, University of California
- Corrine K. Welt
- Division of Endocrinology and Metabolism, University of Utah
- Daniel J. Bernard
- Dept. of Pharmacology and Therapeutics, McGill University
- Stuart C. Sealfon
- Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS)
- DOI
- https://doi.org/10.1038/s41467-021-22859-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mouse pituitaries.
