Nature Communications (Jul 2019)

Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

  • Rajarshi P. Ghosh,
  • Quanming Shi,
  • Linfeng Yang,
  • Michael P. Reddick,
  • Tatiana Nikitina,
  • Victor B. Zhurkin,
  • Polly Fordyce,
  • Timothy J. Stasevich,
  • Howard Y. Chang,
  • William J. Greenleaf,
  • Jan T. Liphardt

DOI
https://doi.org/10.1038/s41467-019-11118-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.