Expression of MK-1 and RegⅣ and its clinicopathological significances in the benign and malignant lesions of gallbladder

Abstract

Abstract Background To study the expression of MK-1 and RegⅣ and to detect their pathological significances in benign and malignant lesions of gallbladder. Methods The expression of MK-1 and RegⅣ was detected by immunohistochemical method in paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35). Results The positive rate of MK-1 or RegⅣ expression was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (χ2MK-1 = 18.76, P 2RegⅣ = 9.92, P 2MK-1 = 9.49, P 2RegⅣ = 8.59, P 2MK-1 = 24.11, P 2RegⅣ = 19.24, P P P P P P = 0.09) or increased expression of RegⅣ (P = 0.003) was associated with decreased overall survival. Multivariate Cox regression analysis showed that decreased expression of MK-1 (P = 0.033) and increased expression of RegⅣ (P = 0.008) was an independent prognostic predictor in gallbladder adenocarcinoma. Conclusions The expression of MK-1 and/or RegⅣ might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.

Keywords

• gallbladder neoplasms
• gallbladder polyp
• chronic cholecystitis
• tumor-associated antigen
• MK-1
• regenerating gene Ⅳ
• immunohistochemistry