International Journal of Nanomedicine (Dec 2022)
Cell Sheet Technology as an Engineering-Based Approach to Bone Regeneration
Abstract
Qi You,1,2,* Minxun Lu,1,2,* Zhuangzhuang Li,1,2 Yong Zhou,1,2 Chongqi Tu1,2 1Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 2Sichuan Model Worker and Craftsman Talent Innovation Research Studio, Chengdu, Sichuan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chongqi Tu; Yong Zhou, Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxuexiang, Chengdu, 610041, Sichuan Province, People’s Republic of China, Email [email protected]; [email protected]: Bone defects that are congenital or the result of infection, malignancy, or trauma represent a challenge to the global healthcare system. To address this issue, multiple research groups have been developing novel cell sheet technology (CST)-based approaches to promote bone regeneration. These methods hold promise for use in regenerative medicine because they preserve cell-cell contacts, cell-extracellular matrix interactions, and the protein makeup of cell membranes. This review introduces the concept and preparation system of the cell sheet (CS), explores the application of CST in bone regeneration, highlights the current states of the bone regeneration via CST, and offers perspectives on the challenges and future research direction of translating current knowledge from the lab to the clinic.Keywords: bone defect, cell sheet technology, bone regeneration, bone tissue engineering
