Nature Communications (Jul 2017)
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
- Sara M. Willems,
- Daniel J. Wright,
- Felix R. Day,
- Katerina Trajanoska,
- Peter K. Joshi,
- John A. Morris,
- Amy M. Matteini,
- Fleur C. Garton,
- Niels Grarup,
- Nikolay Oskolkov,
- Anbupalam Thalamuthu,
- Massimo Mangino,
- Jun Liu,
- Ayse Demirkan,
- Monkol Lek,
- Liwen Xu,
- Guan Wang,
- Christopher Oldmeadow,
- Kyle J. Gaulton,
- Luca A. Lotta,
- Eri Miyamoto-Mikami,
- Manuel A. Rivas,
- Tom White,
- Po-Ru Loh,
- Mette Aadahl,
- Najaf Amin,
- John R. Attia,
- Krista Austin,
- Beben Benyamin,
- Søren Brage,
- Yu-Ching Cheng,
- Paweł Cięszczyk,
- Wim Derave,
- Karl-Fredrik Eriksson,
- Nir Eynon,
- Allan Linneberg,
- Alejandro Lucia,
- Myosotis Massidda,
- Braxton D. Mitchell,
- Motohiko Miyachi,
- Haruka Murakami,
- Sandosh Padmanabhan,
- Ashutosh Pandey,
- Ioannis Papadimitriou,
- Deepak K. Rajpal,
- Craig Sale,
- Theresia M. Schnurr,
- Francesco Sessa,
- Nick Shrine,
- Martin D. Tobin,
- Ian Varley,
- Louise V. Wain,
- Naomi R. Wray,
- Cecilia M. Lindgren,
- Daniel G. MacArthur,
- Dawn M. Waterworth,
- Mark I. McCarthy,
- Oluf Pedersen,
- Kay-Tee Khaw,
- Douglas P. Kiel,
- GEFOS Any-Type of Fracture Consortium,
- Yannis Pitsiladis,
- Noriyuki Fuku,
- Paul W. Franks,
- Kathryn N. North,
- Cornelia M. van Duijn,
- Karen A. Mather,
- Torben Hansen,
- Ola Hansson,
- Tim Spector,
- Joanne M. Murabito,
- J. Brent Richards,
- Fernando Rivadeneira,
- Claudia Langenberg,
- John R. B. Perry,
- Nick J. Wareham,
- Robert A. Scott
Affiliations
- Sara M. Willems
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Daniel J. Wright
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Felix R. Day
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Katerina Trajanoska
- Department of Internal Medicine, Erasmus Medical Center
- Peter K. Joshi
- Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- John A. Morris
- Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
- Amy M. Matteini
- Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine
- Fleur C. Garton
- Queensland Brain Institute, University of Queensland
- Niels Grarup
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Nikolay Oskolkov
- Department of Clinical Sciences, Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
- Anbupalam Thalamuthu
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Massimo Mangino
- Department of Twin Research & Genetic Epidemiology, Kings College London
- Jun Liu
- Department of Epidemiology, Erasmus Medical Center
- Ayse Demirkan
- Department of Epidemiology, Erasmus Medical Center
- Monkol Lek
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Liwen Xu
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Guan Wang
- Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
- Christopher Oldmeadow
- Hunter Medical Research Institute
- Kyle J. Gaulton
- Department of Pediatrics, University of California San Diego
- Luca A. Lotta
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Eri Miyamoto-Mikami
- Japan Society for the Promotion of Science
- Manuel A. Rivas
- Department of Biomedical Data Sciences, Stanford University
- Tom White
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Po-Ru Loh
- BROAD Institute of the Massachusetts Institute of Technology and Harvard University
- Mette Aadahl
- Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital
- Najaf Amin
- Department of Epidemiology, Erasmus Medical Center
- John R. Attia
- Hunter Medical Research Institute
- Krista Austin
- Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
- Beben Benyamin
- Queensland Brain Institute, University of Queensland
- Søren Brage
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Yu-Ching Cheng
- Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Paweł Cięszczyk
- Faculty of Physical Education, Gdańsk University of Physical Education and Sport
- Wim Derave
- Department of Movement and Sports Sciences, Ghent University
- Karl-Fredrik Eriksson
- Department of Clinical Sciences, Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
- Nir Eynon
- Institute of Sport, Exercise & Active Living (ISEAL), Victoria University
- Allan Linneberg
- Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital
- Alejandro Lucia
- Universidad Europea de Madrid
- Myosotis Massidda
- Department of Life and Environmental Sciences, University of Cagliari
- Braxton D. Mitchell
- Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Motohiko Miyachi
- National Institutes of Biomedical Innovation, Health and Nutrition
- Haruka Murakami
- National Institutes of Biomedical Innovation, Health and Nutrition
- Sandosh Padmanabhan
- British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Ashutosh Pandey
- Target Sciences, GlaxoSmithKline
- Ioannis Papadimitriou
- Institute of Sport, Exercise & Active Living (ISEAL), Victoria University
- Deepak K. Rajpal
- Target Sciences, GlaxoSmithKline
- Craig Sale
- Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University
- Theresia M. Schnurr
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Francesco Sessa
- Department of Clinical and Experimental Medicine, Medical Genetics, University of Foggia
- Nick Shrine
- Department of Health Sciences, University of Leicester
- Martin D. Tobin
- Department of Health Sciences, University of Leicester
- Ian Varley
- Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University
- Louise V. Wain
- Department of Health Sciences, University of Leicester
- Naomi R. Wray
- Queensland Brain Institute, University of Queensland
- Cecilia M. Lindgren
- BROAD Institute of the Massachusetts Institute of Technology and Harvard University
- Daniel G. MacArthur
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Dawn M. Waterworth
- Target Sciences, GlaxoSmithKline
- Mark I. McCarthy
- Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Kay-Tee Khaw
- Department of Public Health and Primary Care, University of Cambridge
- Douglas P. Kiel
- Harvard Medical School
- GEFOS Any-Type of Fracture Consortium
- Yannis Pitsiladis
- Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
- Noriyuki Fuku
- Graduate School of Health and Sports Science, Juntendo University
- Paul W. Franks
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skånes University Hospital
- Kathryn N. North
- Murdoch Children’s Research Institute, Royal Children’s Hospital
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus Medical Center
- Karen A. Mather
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Ola Hansson
- Department of Clinical Sciences, Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
- Tim Spector
- Department of Twin Research & Genetic Epidemiology, Kings College London
- Joanne M. Murabito
- Department of Medicine, Boston University School of Medicine, Section of General Internal Medicine
- J. Brent Richards
- Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus Medical Center
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- John R. B. Perry
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Nick J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Robert A. Scott
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- DOI
- https://doi.org/10.1038/ncomms16015
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.
