Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’s Disease

Abstract

- Intrahippocampal amyloid β (Aβ) negatively affects synaptic plasticity with subsequent impairment of learning and memory. Trigonelline is an alkaloid commonly found in fenugreek seeds and coffee beans with neuroprotective property and a promising agent for management of neurodegenerative disorders like Alzheimer’s disease (AD). In the present study, the possible beneficial effect of trigonelline on the improvement of learning and memory and synaptic plasticity was evaluated in Aβ (1-40) rat model of AD. For modeling AD, aggregated A

Keywords

• Trigonelline
• Alzheimer’s disease
• Amyloid β
• Learning and memory
• Synaptic plasticity
• Long-term potentiation