Frontiers in Immunology (Feb 2024)
The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment
- Xiru Liu,
- Xiru Liu,
- Xiru Liu,
- Hao Zhang,
- Hao Zhang,
- Hao Zhang,
- Guolin Shi,
- Guolin Shi,
- Guolin Shi,
- Xinmin Zheng,
- Xinmin Zheng,
- Xinmin Zheng,
- Jing Chang,
- Jing Chang,
- Jing Chang,
- Jing Chang,
- Quande Lin,
- Zhenhao Tian,
- Zhenhao Tian,
- Zhenhao Tian,
- Hui Yang,
- Hui Yang,
- Hui Yang
Affiliations
- Xiru Liu
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Xiru Liu
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Xiru Liu
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Hao Zhang
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Hao Zhang
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Hao Zhang
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Guolin Shi
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Guolin Shi
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Guolin Shi
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Xinmin Zheng
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Xinmin Zheng
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Xinmin Zheng
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Jing Chang
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Jing Chang
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Jing Chang
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Jing Chang
- Medical Service, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
- Quande Lin
- Medical Service, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
- Zhenhao Tian
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Zhenhao Tian
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Zhenhao Tian
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- Hui Yang
- School of Life Sciences, Northwestern Polytechnical University, Xi'an, China
- Hui Yang
- Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Xi'an, China
- Hui Yang
- Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi'an, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1338178
- Journal volume & issue
-
Vol. 15
Abstract
Hematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment. The gut microbiota, a dynamic community residing on the mucosal surface of vertebrates, plays a crucial role in maintaining host health. Recent evidence suggests that the gut microbiota influences HSCs differentiation by modulating the bone marrow microenvironment through microbial products. This paper comprehensively analyzes the impact of the gut microbiota on hematopoiesis and its effect on HSCs fate and differentiation by modifying the bone marrow microenvironment, including mechanical properties, inflammatory signals, bone marrow stromal cells, and metabolites. Furthermore, we discuss the involvement of the gut microbiota in the development of hematologic malignancies, such as leukemia, multiple myeloma, and lymphoma.
Keywords
- bone marrow microenvironment
- gut microbiota
- hematopoietic stem cells
- hematologic malignancies
- immune cells
- broad-spectrum antibiotics
