Activity Of Ciprofloxacin and Resveratrol On Expression Of AdeI J Genes In Clinical Acinetobacter baumannii Isolates

Abstract

• baumannii considered one important pathogenic bacteria and responsible for several nosocomial and community infections for human and , possess the ability to form biofilms , and continued development of antibiotic resistance to drugs used to treat bacterial infections . Current study was performed ,during the period from 1/9 /2022 to the end of December 30 /12 /2022 ,a total of 210 of blood specimens were collected in Baqubah Teaching Hospital /Iraq to investigate the prevalence of bacterial isolates among patients in Intensive Care Unit (ICU) , detect antibiotic resistance , biofilms formation , molecular detection of efflux pumps adeIJ genes ,and activity of ciprofloxacin and resveratrol on expression of this two genes. The results revealed that that the percentage of positive growth of A. baumannii which isolates from blood samples with among ICU patients were 12 % , presence of highest resistance of 25 isolates against fourteen types of antibiotics, our finding showed significant differences before and after treatment of resistance isolates with Resveratrol with a higher reduction expression of AdeIJ genes in all isolates under study were reach 0.59 and 0.28 respectively.

Keywords

• A . baumannii, AdeI J genes , Antibiotic , Efflux pump inhibitors