Pharmaceutics (Jan 2021)
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease
- Sara Salvador-Martín,
- Bartosz Kaczmarczyk,
- Rebeca Álvarez,
- Víctor Manuel Navas-López,
- Carmen Gallego-Fernández,
- Ana Moreno-Álvarez,
- Alfonso Solar-Boga,
- Cesar Sánchez,
- Mar Tolin,
- Marta Velasco,
- Rosana Muñoz-Codoceo,
- Alejandro Rodriguez-Martinez,
- Concepción A. Vayo,
- Ferrán Bossacoma,
- Gemma Pujol-Muncunill,
- María J. Fobelo,
- Antonio Millán-Jiménez,
- Lorena Magallares,
- Eva Martínez-Ojinaga,
- Inés Loverdos,
- Francisco J. Eizaguirre,
- José A. Blanca-García,
- Susana Clemente,
- Ruth García-Romero,
- Vicente Merino-Bohórquez,
- Rafael González de Caldas,
- Enrique Vázquez,
- Ana Dopazo,
- María Sanjurjo-Sáez,
- Luis A. López-Fernández
Affiliations
- Sara Salvador-Martín
- Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Bartosz Kaczmarczyk
- Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Rebeca Álvarez
- Genomics Unit, Spanish Nacional Center for Cardiovascular Diseases (CNIC), 28029 Madrid, Spain
- Víctor Manuel Navas-López
- Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, IBIMA Multidisciplinary Group for Pediatric Research, 29010 Málaga, Spain
- Carmen Gallego-Fernández
- Pharmacy Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
- Ana Moreno-Álvarez
- Pediatric Gastroenterology Unit, Department of Pediatrics, A Coruña University Hospital, 15006 A Coruña, Spain
- Alfonso Solar-Boga
- Pediatric Gastroenterology Unit, Department of Pediatrics, A Coruña University Hospital, 15006 A Coruña, Spain
- Cesar Sánchez
- Gastroenterology Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Mar Tolin
- Gastroenterology Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Marta Velasco
- Department of Pediatric Gastroenterology, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain
- Rosana Muñoz-Codoceo
- Department of Pediatric Gastroenterology, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain
- Alejandro Rodriguez-Martinez
- Pediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Universitario Virgen del Rocio, 41013 Seville, Spain
- Concepción A. Vayo
- Pharmacy Service, Hospital Universitario Virgen del Rocio, 41013 Seville, Spain
- Ferrán Bossacoma
- Fundació Sant Joan de Déu, Fundació Salut Emporda, 08950 Barcelona, Spain
- Gemma Pujol-Muncunill
- Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
- María J. Fobelo
- Pharmacy Service, Hospital Virgen de Valme, 41014 Sevilla, Spain
- Antonio Millán-Jiménez
- Pediatric Gastroenterology Unit, Hospital Virgen de Valme, 41014 Sevilla, Spain
- Lorena Magallares
- Department of Pediatric Gastroenterology, University Hospital La Paz, 28046 Madrid, Spain
- Eva Martínez-Ojinaga
- Department of Pediatric Gastroenterology, University Hospital La Paz, 28046 Madrid, Spain
- Inés Loverdos
- Pediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital de Sabadell, Corporació Sanitària Universitària Parc Taulí, 08208 Barcelona, Spain
- Francisco J. Eizaguirre
- Pediatric Gastroenterology Unit, Hospital Universitario Donostia, 20014 San Sebastián, Spain
- José A. Blanca-García
- Pediatric Gastroenterology Unit, Hospital Puerta del Mar, 11009 Cadiz, Spain
- Susana Clemente
- Pharmacy Unit, Hospital Universitario Vall d’Hebrón, 08035 Barcelona, Spain
- Ruth García-Romero
- Pediatric Gastroenterology Unit, Hospital Infantil Miguel Servet, 50009 Zaragoza, Spain
- Vicente Merino-Bohórquez
- UGC Pharmacy Department, Hospital Virgen de la Macarena, 41009 Sevilla, Spain
- Rafael González de Caldas
- Pediatric Gastroenterology Unit, Hospital Reina Sofía, 14004 Córdoba, Spain
- Enrique Vázquez
- Genomics Unit, Spanish Nacional Center for Cardiovascular Diseases (CNIC), 28029 Madrid, Spain
- Ana Dopazo
- Genomics Unit, Spanish Nacional Center for Cardiovascular Diseases (CNIC), 28029 Madrid, Spain
- María Sanjurjo-Sáez
- Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Luis A. López-Fernández
- Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- DOI
- https://doi.org/10.3390/pharmaceutics13010077
- Journal volume & issue
-
Vol. 13,
no. 1
p. 77
Abstract
Background: Up to 30% of patients with pediatric inflammatory bowel disease (IBD) do not respond to anti-Tumor Necrosis Factor (anti-TNF) therapy. The aim of this study was to identify pharmacogenomic markers that predict early response to anti-TNF drugs in pediatric patients with IBD. Methods: An observational, longitudinal, prospective cohort study was conducted. The study population comprised 38 patients with IBD aged 0.6 or p value FCGR1A, FCGR1B, and GBP1 were overexpressed in non-responders two weeks after initiation of anti-TNF treatment (Log2FC 1.05, 1.21, and 1.08, respectively, p value FCGR1A, FCGR1B, and GBP1 genes is a pharmacogenomic biomarker of early response to anti-TNF agents in pediatric IBD.
Keywords
