A role for GABA in the modulation of striatal and hippocampal systems under stress

Nina Dolfen; Menno P. Veldman; Mareike A. Gann; Andreas von Leupoldt; Nicolaas A. J. Puts; Richard A. E. Edden; Mark Mikkelsen; Stephan Swinnen; Lars Schwabe; Geneviève Albouy; Bradley R. King

doi:10.1038/s42003-021-02535-x

Communications Biology (Sep 2021)

A role for GABA in the modulation of striatal and hippocampal systems under stress

Nina Dolfen,
Menno P. Veldman,
Mareike A. Gann,
Andreas von Leupoldt,
Nicolaas A. J. Puts,
Richard A. E. Edden,
Mark Mikkelsen,
Stephan Swinnen,
Lars Schwabe,
Geneviève Albouy,
Bradley R. King

Affiliations

Nina Dolfen: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven
Menno P. Veldman: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven
Mareike A. Gann: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven
Andreas von Leupoldt: Health Psychology, KU Leuven
Nicolaas A. J. Puts: Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London
Richard A. E. Edden: Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine
Mark Mikkelsen: Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine
Stephan Swinnen: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven
Lars Schwabe: Department of Cognitive Psychology, Institute of Psychology, University of Hamburg
Geneviève Albouy: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven
Bradley R. King: Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven

DOI: https://doi.org/10.1038/s42003-021-02535-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Using fMRI and MRS measurements from healthy, young adults, Dolfen et al examined the effects of motor learning and stress on striatal and hippocampal GABA levels, as well as effects on neural correlates of learning. They demonstrated that stress modulated the link between striatal GABA levels and functional plasticity in the hippocampus and striatum, which reveals a role for GABA in the stress-induced modulation of these systems.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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