Pediatric Osteochondral Lesions of the Talus: A Systematic Review and Treatment Algorithm

Abstract

Category: Hindfoot; Ankle Introduction/Purpose: Osteochondral lesions of the talus (OLT) peak in incidence during childhood, yet there exists a paucity of research on treatment among skeletally immature populations due to their high potential for spontaneous recovery without interventions. Unfortunately for patients who do require treatment, existing guidelines are based on adult studies, which likely differ in prognoses and outcomes due to varying capacity for regeneration. This paper compares outcomes across conservative and various surgical interventions for pediatric OLTs, with the synthesized evidence forming the basis of a treatment algorithm. Methods: An electronic literature search was conducted across PubMed, EMBASE, and MEDLINE databases for primary studies published prior to January 2022. Pediatric status in OLTs was defined as age < 18 at diagnosis, since many studies did not assess skeletal maturity. The main outcomes were clinical and radiological success rates, defined as achievement of good or fair outcomes according to measures used by individual studies. Articles were categorized by treatment method, and outcome rates were obtained via simple pooling. Results: 35 studies involving 714 lesions were included. Studies were categorized into five overarching treatment methods – (1) conservative treatment, (2) bone marrow stimulation, (3) retrograde drilling, (4) fixation, and (5) osteochondral transplantation. These interventions had pooled clinical success rates of (1) 45%, (2) 85%, (2) 90%, (4) 82%, and (5) 74%, respectively. The pooled radiological success rates were (1) 58%, (2) 85%, (3) 55%, (4) 89%, and (5) 81%. Escalation from conservative to surgical treatment occurred at a rate of 62% among studies in which this was reported. Articles were heterogeneous in measurement tools and pre- treatment characteristics; average baseline lesion size was (1) 129.8, (2) 131.0, (3) 87.8, (4) 137.8, and (5) 237.5mm^2 across the five treatment methods, and initial Berndt-Harty staging was likewise disparate. Conclusion: Conservative treatments yielded lower clinical and radiological success rates than surgical interventions, but warrant an initial trial in stable lesions due to their cost-effective and non-invasive nature. Surgery should be indicated for unstable lesions, or failed conservative treatment. Drilling and bone marrow stimulation are effective in lower grade lesions, while fixation should be considered for loosened fragments, and transplantation for large, non-salvageable lesions. Future research utilizing more robust methodology and reporting outcomes according to baseline lesion characteristics will consolidate these guidelines.