Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

Michele Correale; Lucia Tricarico; Francesca Croella; Simona Alfieri; Francesco Fioretti; Natale Daniele Brunetti; Riccardo M. Inciardi; Savina Nodari

doi:10.3389/fcvm.2023.1157472

Frontiers in Cardiovascular Medicine (Jun 2023)

Novelties in the pharmacological approaches for chronic heart failure: new drugs and cardiovascular targets

Michele Correale,
Lucia Tricarico,
Francesca Croella,
Simona Alfieri,
Francesco Fioretti,
Natale Daniele Brunetti,
Riccardo M. Inciardi,
Savina Nodari

Affiliations

Michele Correale: Department of Cardiothoracic, Policlinico Riuniti University Hospital, Foggia, Italy
Lucia Tricarico: Department of Cardiothoracic, Policlinico Riuniti University Hospital, Foggia, Italy
Francesca Croella: Department of Medical & Surgical Sciences, University of Foggia, Foggia, Italy
Simona Alfieri: Department of Medical & Surgical Sciences, University of Foggia, Foggia, Italy
Francesco Fioretti: Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili Hospital and University of Brescia, Brescia, Italy
Natale Daniele Brunetti: Department of Medical & Surgical Sciences, University of Foggia, Foggia, Italy
Riccardo M. Inciardi: Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili Hospital and University of Brescia, Brescia, Italy
Savina Nodari: Cardiology Section, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili Hospital and University of Brescia, Brescia, Italy

DOI: https://doi.org/10.3389/fcvm.2023.1157472
Journal volume & issue: Vol. 10

Abstract

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Despite recent advances in chronic heart failure (HF) management, the prognosis of HF patients is poor. This highlights the need for researching new drugs targeting, beyond neurohumoral and hemodynamic modulation approach, such as cardiomyocyte metabolism, myocardial interstitium, intracellular regulation and NO-sGC pathway. In this review we report main novelties on new possible pharmacological targets for HF therapy, mainly on new drugs acting on cardiac metabolism, GCs-cGMP pathway, mitochondrial function and intracellular calcium dysregulation.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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