Fosfomycin, a therapeutic option for infections produced by multiple drug-resistant Enterobacteriaceae

Abstract

Due to the increasing prevalence of infections caused by resistant bacteria and especially multiple drug resistance Enterobacteriaceae, availability of alternative effective antibiotics is restricted. The goal of this study was to investigate the susceptibility profile of multiple drug resistance and extensively drug resistance Enterobacteriaceae isolated from various clinical samples to fosfomycin. A total of 303 non-duplicate Enterobacteriaceae isolates were collected. Identification and susceptibility testing were done according to standard microbiological procedures and the Kirby-Bauer test, respectively. Of all isolates, 272 (89.8%) and 26 (8.6%) were detected as multiple drug resistance and extensively drug resistance strains, respectively. The most effective antibiotic (98%) was fosfomycin, when compared with other antibiotics against multiple drug resistance and extensively drug resistance Enterobacteriaceae isolates. In this study, we find high levels of resistance to commonly used antibiotics. However, fosfomycin can be a good option for treating multiple drug resistance Enterobacteriaceae.

Keywords

• Enterobacteriaceae
• ESBL
• fosfomycin
• multiple drug resistance
• extensively drug resistance