Frontiers in Nutrition (Oct 2022)
Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study
- Silja H. Overgaard,
- Silja H. Overgaard,
- Silja H. Overgaard,
- Signe B. Sørensen,
- Signe B. Sørensen,
- Heidi L. Munk,
- Anders B. Nexøe,
- Anders B. Nexøe,
- Anders B. Nexøe,
- Henning Glerup,
- Rikke H. Henriksen,
- Tanja Guldmann,
- Natalia Pedersen,
- Sanaz Saboori,
- Lone Hvid,
- Jens F. Dahlerup,
- Christian L. Hvas,
- Mohamad Jawhara,
- Mohamad Jawhara,
- Mohamad Jawhara,
- Karina W. Andersen,
- Karina W. Andersen,
- Andreas K. Pedersen,
- Ole H. Nielsen,
- Fredrik Bergenheim,
- Jacob B. Brodersen,
- Jacob B. Brodersen,
- Berit L. Heitmann,
- Berit L. Heitmann,
- Thorhallur I. Halldorsson,
- Uffe Holmskov,
- Anette Bygum,
- Anette Bygum,
- Robin Christensen,
- Robin Christensen,
- Jens Kjeldsen,
- Jens Kjeldsen,
- Torkell Ellingsen,
- Vibeke Andersen,
- Vibeke Andersen,
- Vibeke Andersen
Affiliations
- Silja H. Overgaard
- The Molecular Diagnostics and Clinical Research Unit, Departement of Blood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark
- Silja H. Overgaard
- Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
- Silja H. Overgaard
- Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
- Signe B. Sørensen
- The Molecular Diagnostics and Clinical Research Unit, Departement of Blood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark
- Signe B. Sørensen
- Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Heidi L. Munk
- Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark
- Anders B. Nexøe
- Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Anders B. Nexøe
- Department of Cancer and Inflammation Research, Odense University Hospital, Odense, Denmark
- Anders B. Nexøe
- Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark
- Henning Glerup
- University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark
- Rikke H. Henriksen
- University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark
- Tanja Guldmann
- University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark
- Natalia Pedersen
- Department of Gastroenterology, Slagelse Hospital, Slagelse, Denmark
- Sanaz Saboori
- Department of Gastroenterology, Slagelse Hospital, Slagelse, Denmark
- Lone Hvid
- 0Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark
- Jens F. Dahlerup
- 1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
- Christian L. Hvas
- 1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
- Mohamad Jawhara
- The Molecular Diagnostics and Clinical Research Unit, Departement of Blood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark
- Mohamad Jawhara
- Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Mohamad Jawhara
- 2Department of Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark
- Karina W. Andersen
- The Molecular Diagnostics and Clinical Research Unit, Departement of Blood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark
- Karina W. Andersen
- 2Department of Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark
- Andreas K. Pedersen
- 3Department of Research and Learning, University Hospital of Southern Denmark, Aabenraa, Denmark
- Ole H. Nielsen
- 4Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
- Fredrik Bergenheim
- 4Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
- Jacob B. Brodersen
- Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
- Jacob B. Brodersen
- 5Department of Gastroenterology, Hospital of Southwest Jutland, Esbjerg, Denmark
- Berit L. Heitmann
- 6Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
- Berit L. Heitmann
- 7Section for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Thorhallur I. Halldorsson
- 8Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Reykjavík, Iceland
- Uffe Holmskov
- Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Anette Bygum
- 0Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark
- Anette Bygum
- 9Clinical Institute, University of Southern Denmark, Odense, Denmark
- Robin Christensen
- Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
- Robin Christensen
- Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark
- Jens Kjeldsen
- Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark
- Jens Kjeldsen
- 0Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
- Torkell Ellingsen
- Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark
- Vibeke Andersen
- The Molecular Diagnostics and Clinical Research Unit, Departement of Blood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark
- Vibeke Andersen
- Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Vibeke Andersen
- 1Open Patient Data Explorative Network, Department of Clinical Research, University of Southern, Odense, Denmark
- DOI
- https://doi.org/10.3389/fnut.2022.985732
- Journal volume & issue
-
Vol. 9
Abstract
BackgroundBiologic disease-modifying drugs have revolutionised the treatment of a number of chronic inflammatory diseases (CID). However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for optimization of treatment strategies.ObjectiveTo investigate if the treatment outcome of biological therapy is associated with the habitual dietary intake of fibre and red/processed meat in patients with a CID.MethodsIn this multicentre prospective cohort study, we consecutively enrolled 233 adult patients with a diagnosis of Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis (RA), Axial Spondyloarthritis, Psoriatic Arthritis and Psoriasis, for whom biologic therapy was planned, over a 3 year period. Patients with completed baseline food frequency questionnaires were stratified into a high fibre/low red and processed meat exposed group (HFLM) and an unexposed group (low fibre/high red and processed meat intake = LFHM). The primary outcome was the proportion of patients with a clinical response to biologic therapy after 14–16 weeks of treatment.ResultsOf the 193 patients included in our primary analysis, 114 (59%) had a clinical response to biologic therapy. In the HFLM group (N = 64), 41 (64%) patients responded to treatment compared to 73 (56%) in the LFHM group (N = 129), but the difference was not statistically significant (OR: 1.48, 0.72–3.05). For RA patients however, HFLM diet was associated with a more likely clinical response (82% vs. 35%; OR: 9.84, 1.35–71.56).ConclusionHabitual HFLM intake did not affect the clinical response to biological treatment across CIDs. HFLM diet in RA patients might be associated with better odds for responding to biological treatment, but this would need confirmation in a randomised trial.Trial registration(clinicaltrials.gov), identifier [NCT03173144].
Keywords
