CHMP4C: A novel regulator of the mitotic spindle checkpoint

Abstract

The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery, protects human cells against chromosome missegregation by promoting localisation of the ROD–ZW10–ZWILCH (RZZ) spindle checkpoint complex to unattached kinetochores.

Keywords

• chmp4c
• spindle checkpoint
• mitosis
• rzz
• escrt
• zw10
• biology of malignant cells