Influence of Parameters on Photodynamic Therapy of Au@TiO<sub>2</sub>–HMME Core-Shell Nanostructures

Ping Wang; Luwei Zhang; Zhenxi Zhang; Sijia Wang; Cuiping Yao

doi:10.3390/nano12081358

Nanomaterials (Apr 2022)

Influence of Parameters on Photodynamic Therapy of Au@TiO<sub>2</sub>–HMME Core-Shell Nanostructures

Ping Wang,
Luwei Zhang,
Zhenxi Zhang,
Sijia Wang,
Cuiping Yao

Affiliations

Ping Wang: Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Luwei Zhang: Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Zhenxi Zhang: Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Sijia Wang: Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Cuiping Yao: Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China

DOI: https://doi.org/10.3390/nano12081358
Journal volume & issue: Vol. 12, no. 8
p. 1358

Abstract

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Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. However, as an amphiphilic photosensitizer, HMME is easy to aggregate due to the presence of a hydrophobic group, which undesirably reduced its generation of singlet oxygen and bioavailability. In this study, we synthesized the stable conjugate of Au@TiO2 core-shell nanostructure with HMME, and the influence of different factors on PTD efficiency were studied. The results showed that the nanostructure had higher PTD efficiency for KB cells than that of HMME. The irradiation wavelength, gold nanoparticle shape and the shell thickness are all important factors for KB cell PDT.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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