A Comparison of RAMP Troponin Test Results with Highly Sensitive Laboratory Troponin in Patients Suspected of Acute Myocardial Infarction

Abstract

Introduction: Current guidelines recommend using high-sensitivity troponin (hs-cTnl) assays to manage patients with acute coronary syndrome (ACS) symptoms. Despite this, bedside testing (POC) is commonly used in the emergency room, as it reduces the patient's response time and hospital stay. This study seeks to compare the results of the RAMP- cTnI test with the results of laboratory troponin (hs-cTnl) as the gold standard.Methods: The present study was performed on 148 patients with suspected acute coronary syndrome referred to Shiraz Namazi Hospital between March and July 2021. Blood samples were taken immediately from patients referred to the emergency department for POC and high-sensitivity troponin test (as gold standard). Enzyme-Linked Fluorescent Assay (ELFA) was used to evaluate troponin (cTnl). The POC test was performed using a RAMP device, which allows the rapid measurement of cTnl in the patient's bedside within 10 minutes using a whole blood sample.Results: Of the 148 patients, 35 were hs-cTnI positive. Sensitivity, specificity, the positive and negative predictive values of RAMP- cTnI compared to high sensitivity test with 95% confidence interval were 91.42 (93.63-85.84), 94.69% (97.95%-87.55), 84.21% (93.56-77.82) and 97.27% (99.56-87.82), respectively.Conclusion: The study showed that the quantitatively new RAMP- cTnI method was statistically acceptable with hs - cTnI regarding the accuracy of acute myocardial infarction. RAMP- cTnI was found to be suitable for detecting acute myocardial infarction in the emergency department.

Keywords

• acute coronary syndrome
• troponin i
• point-of-care testing