Nature Communications (Dec 2021)
Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma
- Wei Cheng,
- Hao-Long Li,
- Shao-Yan Xi,
- Xiao-Feng Zhang,
- Yun Zhu,
- Le Xing,
- Yan-Xuan Mo,
- Mei-Mei Li,
- Fan-En Kong,
- Wen-Jie Zhu,
- Xiao-Gang Chen,
- Hui-Qing Cui,
- Zhi-Ming Cao,
- Yuan-Feng Gong,
- Yun-Qiang Tang,
- Yan Zhang,
- Xin-Yuan Guan,
- Ning-Fang Ma,
- Ming Liu
Affiliations
- Wei Cheng
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Hao-Long Li
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Shao-Yan Xi
- State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Xiao-Feng Zhang
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Yun Zhu
- Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Le Xing
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Yan-Xuan Mo
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Mei-Mei Li
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Fan-En Kong
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Wen-Jie Zhu
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Xiao-Gang Chen
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Hui-Qing Cui
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Zhi-Ming Cao
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Yuan-Feng Gong
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Yun-Qiang Tang
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Yan Zhang
- Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Xin-Yuan Guan
- Department of Clinical Oncology, State Key Laboratory for Liver Research, The University of Hong Kong
- Ning-Fang Ma
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Ming Liu
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-021-27525-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Poorly differentiated hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis. Here the authors show that GDF1, a member of the TGF-β superfamily, is highly expressed in high-grade poorly differentiated HCC and is associated with tumor plasticity, and that GDF1-induced reexpression of cancer testis antigens could render tumors sensitive to immune checkpoint inhibition.
