10.04 Spatial transcriptomics identifies metabolic dysregulation as a key driver of T cell exclusion in esophageal adenocarcinoma

• J Sanders,
• TD de Gruijl,
• HWM van Laarhoven,
• J Van den Bossche,
• S Derks,
• EN Bos,
• N Hahn,
• I Nijman,
• DL van der Peet

Affiliations

J Sanders

3Cardiff and Vale University Health Board, UK

TD de Gruijl

1Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands

HWM van Laarhoven

1Amsterdam UMC, Amsterdam, Netherlands

J Van den Bossche

3Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Free University, Amsterdam, Netherlands

S Derks

1Amsterdam UMC, Amsterdam, Netherlands

EN Bos

1Amsterdam UMC location Free University, Medical Oncology; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, Netherlands

N Hahn

3Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Free University, Amsterdam, Netherlands

I Nijman

4Utrecht Sequencing Facility, Utrecht, Netherlands

DL van der Peet

1Amsterdam UMC location Free University, Medical Oncology; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, Netherlands