The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle

Giovanna Rigillo; Valentina Basile; Silvia Belluti; Mirko Ronzio; Elisabetta Sauta; Alessia Ciarrocchi; Lucia Latella; Marielle Saclier; Susanna Molinari; Antonio Vallarola; Graziella Messina; Roberto Mantovani; Diletta Dolfini; Carol Imbriano

doi:10.1038/s41467-021-26293-w

Nature Communications (Oct 2021)

The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle

Giovanna Rigillo,
Valentina Basile,
Silvia Belluti,
Mirko Ronzio,
Elisabetta Sauta,
Alessia Ciarrocchi,
Lucia Latella,
Marielle Saclier,
Susanna Molinari,
Antonio Vallarola,
Graziella Messina,
Roberto Mantovani,
Diletta Dolfini,
Carol Imbriano

Affiliations

Giovanna Rigillo: Department of Life Sciences, University of Modena and Reggio Emilia
Valentina Basile: Department of Life Sciences, University of Modena and Reggio Emilia
Silvia Belluti: Department of Life Sciences, University of Modena and Reggio Emilia
Mirko Ronzio: Department of Biosciences, University of Milan
Elisabetta Sauta: Department of Electrical, Computer and Biomedical Engineering, University of Pavia
Alessia Ciarrocchi: Laboratory of Translational Research, Azienda USL-IRCCS
Lucia Latella: Department of Medicine, Institute of Translational Pharmacology, Italian National Research Council and Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia
Marielle Saclier: Department of Biosciences, University of Milan
Susanna Molinari: Department of Life Sciences, University of Modena and Reggio Emilia
Antonio Vallarola: Department of Life Sciences, University of Modena and Reggio Emilia
Graziella Messina: Department of Biosciences, University of Milan
Roberto Mantovani: Department of Biosciences, University of Milan
Diletta Dolfini: Department of Biosciences, University of Milan
Carol Imbriano: Department of Life Sciences, University of Modena and Reggio Emilia

DOI: https://doi.org/10.1038/s41467-021-26293-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Satellite cells represent myogenic stem cells that allow the homeostasis and repair of adult skeletal muscle. Here the authors report that the transcription factor NF-Y is expressed in satellite cells and is important for their maintenance and proper myogenic differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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