Abstract Staphylococcus aureus bacteremia (SAB) is a severe infectious disease with a heterogenous clinical presentation. To diagnose possible metastatic infection and to start early adequate management including antimicrobial treatment and adequate source control as soon as possible, guidelines recommend additional imaging such as [18F]FDG-PET/CT. In this clinical perspective, we describe the current evidence of [18F]FDG-PET/CT in SAB and we share our view on the value of [18F]FDG-PET/CT in specific SAB patients.
