Nature Communications (Oct 2017)

Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

  • Myriam M. Ouberai,
  • Ana L. Gomes Dos Santos,
  • Sonja Kinna,
  • Shimona Madalli,
  • David C. Hornigold,
  • David Baker,
  • Jacqueline Naylor,
  • Laura Sheldrake,
  • Dominic J. Corkill,
  • John Hood,
  • Paolo Vicini,
  • Shahid Uddin,
  • Steven Bishop,
  • Paul G. Varley,
  • Mark E. Welland

DOI
https://doi.org/10.1038/s41467-017-01114-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.