Erectile Dysfunction Is Associated With Excessive Growth Hormone Levels in Male Patients With Acromegaly

Zhengyuan Chen; Zhengyuan Chen; Zhengyuan Chen; Xiaoqing Shao; Min He; Ming Shen; Ming Shen; Ming Shen; Wei Gong; Meng Wang; Yichao Zhang; Yichao Zhang; Yichao Zhang; Wenjuan Liu; Zengyi Ma; Zengyi Ma; Zengyi Ma; Zhao Ye; Zhao Ye; Zhao Ye; Yongning Lu; Nianqin Yang; Shanwen Chen; Lydia Hu; Yiming Li; Yongfei Wang; Yongfei Wang; Yongfei Wang; Yao Zhao; Yao Zhao; Yao Zhao; Zhaoyun Zhang

doi:10.3389/fendo.2021.633904

Frontiers in Endocrinology (May 2021)

Erectile Dysfunction Is Associated With Excessive Growth Hormone Levels in Male Patients With Acromegaly

Zhengyuan Chen,
Zhengyuan Chen,
Zhengyuan Chen,
Xiaoqing Shao,
Min He,
Ming Shen,
Ming Shen,
Ming Shen,
Wei Gong,
Meng Wang,
Yichao Zhang,
Yichao Zhang,
Yichao Zhang,
Wenjuan Liu,
Zengyi Ma,
Zengyi Ma,
Zengyi Ma,
Zhao Ye,
Zhao Ye,
Zhao Ye,
Yongning Lu,
Nianqin Yang,
Shanwen Chen,
Lydia Hu,
Yiming Li,
Yongfei Wang,
Yongfei Wang,
Yongfei Wang,
Yao Zhao,
Yao Zhao,
Yao Zhao,
Zhaoyun Zhang

Affiliations

Zhengyuan Chen: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Zhengyuan Chen: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Zhengyuan Chen: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Xiaoqing Shao: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Min He: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Ming Shen: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Ming Shen: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Ming Shen: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Wei Gong: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Meng Wang: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Yichao Zhang: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Yichao Zhang: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Yichao Zhang: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Wenjuan Liu: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Zengyi Ma: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Zengyi Ma: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Zengyi Ma: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Zhao Ye: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Zhao Ye: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Zhao Ye: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Yongning Lu: Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
Nianqin Yang: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Shanwen Chen: Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
Lydia Hu: Department of Biochemistry and Cellular and Molecular Biology, College of Arts and Sciences, The University of Tennessee, Knoxville, Knoxville, TX, United States
Yiming Li: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Yongfei Wang: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Yongfei Wang: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Yongfei Wang: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Yao Zhao: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Yao Zhao: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Yao Zhao: Shanghai Key Laboratory of Brain Function and Regeneration, Huashan Hospital, Fudan University, Shanghai, China
Zhaoyun Zhang: Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fendo.2021.633904
Journal volume & issue: Vol. 12

Abstract

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ObjectiveTo determine the risk factors for erectile dysfunction (ED) in male patients with acromegaly and to prospectively investigate the short-term changes of erectile function after surgery or medical treatment.MethodsSixty-three male patients were subjected to nocturnal penile tumescence and rigidity (NPTR) test for the evaluation of erectile function. The measurement of serum nitric oxide (NO) was also performed. Twenty-seven patients were re-evaluated by NPTR after surgery or long-term somatostatin analogues (SSA) treatment.ResultsTwenty-two patients (34.9%) had ED. Patients with ED showed higher random GH (17.89 [10.97-44.19] μg/L vs 11.63 [4.31-28.80] μg/L, p = 0.020) and GH nadir (GHn) (10.80 [6.69-38.30] μg/L vs 8.76 [3.62-18.19] μg/L, p = 0.044) during oral glucose tolerance test (OGTT). The NO levels of ED patients were lower than non-ED patients (9.15 [5.58-22.48] μmol/L vs 16.50 [12.33-31.78] μmol/L, p = 0.012). After treatment, patients who present improvement in erectile function showed lower post-GHn (0.07 [0.03-0.12] ng/ml vs 1.32 [0.09-3.60] ng/ml, p = 0.048) and post-IGF-1 index (1.03 ± 0.38 vs 1.66 ± 0.95, p = 0.049). The multivariate analysis indicated post-GHn was still associated with the improvement of erectile function after correction of other covariates (OR: 0.059, 95% CI: 0.003-1.043, p = 0.053).ConclusionsExcessive GH is related to ED in male patients with acromegaly. GH normalization after treatment is beneficial for short-term erectile function recovery.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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