Nature Communications (Feb 2018)
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury
- Konstantina-Ioanna Sereti,
- Ngoc B. Nguyen,
- Paniz Kamran,
- Peng Zhao,
- Sara Ranjbarvaziri,
- Shuin Park,
- Shan Sabri,
- James L. Engel,
- Kevin Sung,
- Rajan P. Kulkarni,
- Yichen Ding,
- Tzung K. Hsiai,
- Kathrin Plath,
- Jason Ernst,
- Debashis Sahoo,
- Hanna K.A. Mikkola,
- M. Luisa Iruela-Arispe,
- Reza Ardehali
Affiliations
- Konstantina-Ioanna Sereti
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Ngoc B. Nguyen
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Paniz Kamran
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Peng Zhao
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Sara Ranjbarvaziri
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Shuin Park
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Shan Sabri
- Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles
- James L. Engel
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Kevin Sung
- Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Rajan P. Kulkarni
- Jonsson Comprehensive Cancer Center
- Yichen Ding
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Tzung K. Hsiai
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Kathrin Plath
- Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles
- Jason Ernst
- Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles
- Debashis Sahoo
- Departments of Pediatrics and Computer Science and Engineering, University of California San Diego
- Hanna K.A. Mikkola
- Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles
- M. Luisa Iruela-Arispe
- Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles
- Reza Ardehali
- Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles
- DOI
- https://doi.org/10.1038/s41467-018-02891-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
During cardiac tissue formation it is unclear whether newly generated myocytes originate from cardiac progenitor cells or from pre-existing cardiomyocytes. Here, the authors use a stochastic four-colour reporter system (Rainbow) to identify the source of new cardiomyocytes during mouse development.
