Nature Communications (Oct 2020)
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
- Clara A. Moreau,
- Sebastian G. W. Urchs,
- Kumar Kuldeep,
- Pierre Orban,
- Catherine Schramm,
- Guillaume Dumas,
- Aurélie Labbe,
- Guillaume Huguet,
- Elise Douard,
- Pierre-Olivier Quirion,
- Amy Lin,
- Leila Kushan,
- Stephanie Grot,
- David Luck,
- Adrianna Mendrek,
- Stephane Potvin,
- Emmanuel Stip,
- Thomas Bourgeron,
- Alan C. Evans,
- Carrie E. Bearden,
- Pierre Bellec,
- Sebastien Jacquemont
Affiliations
- Clara A. Moreau
- Sainte Justine Hospital Research Center, University of Montreal
- Sebastian G. W. Urchs
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal
- Kumar Kuldeep
- Sainte Justine Hospital Research Center, University of Montreal
- Pierre Orban
- Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal
- Catherine Schramm
- Sainte Justine Hospital Research Center, University of Montreal
- Guillaume Dumas
- Sainte Justine Hospital Research Center, University of Montreal
- Aurélie Labbe
- Département des Sciences de la Décision, HEC
- Guillaume Huguet
- Sainte Justine Hospital Research Center, University of Montreal
- Elise Douard
- Sainte Justine Hospital Research Center, University of Montreal
- Pierre-Olivier Quirion
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal
- Amy Lin
- Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California, Los Angeles, Semel Institute/NPI
- Leila Kushan
- Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California, Los Angeles, Semel Institute/NPI
- Stephanie Grot
- Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal
- David Luck
- Sainte Justine Hospital Research Center, University of Montreal
- Adrianna Mendrek
- Department of Psychology, Bishop’s University
- Stephane Potvin
- Département de Psychiatrie et d’Addictologie, Université de Montréal, Pavillon Roger-Gaudry
- Emmanuel Stip
- Département de Psychiatrie et d’Addictologie, Université de Montréal, Pavillon Roger-Gaudry
- Thomas Bourgeron
- Human Genetics and Cognitive Functions, Institut Pasteur, Université de Paris
- Alan C. Evans
- Montreal Neurological Institute and Hospital, McGill University
- Carrie E. Bearden
- Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California, Los Angeles, Semel Institute/NPI
- Pierre Bellec
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal
- Sebastien Jacquemont
- Sainte Justine Hospital Research Center, University of Montreal
- DOI
- https://doi.org/10.1038/s41467-020-18997-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The impact of neurodevelopmental mutations on functional brain connectivity is poorly understood. Here the authors identify thalamo-sensorimotor dysconnectivity dimensions shared across 16p11.2 and 22q11.2 copy number variants, autism and schizophrenia, but not ADHD.
