Nature Communications (Feb 2023)

Dynamic interplay between non-coding enhancer transcription and gene activity in development

  • Kota Hamamoto,
  • Yusuke Umemura,
  • Shiho Makino,
  • Takashi Fukaya

DOI
https://doi.org/10.1038/s41467-023-36485-1
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 17

Abstract

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Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via surrounding non-coding transcription.