The global role of G6PD in infection and immunity

Shivang S. Shah; Elizabeth F. Stone; Richard O. Francis; Matthew S. Karafin

doi:10.3389/fimmu.2024.1393213

Frontiers in Immunology (Jun 2024)

The global role of G6PD in infection and immunity

Shivang S. Shah,
Elizabeth F. Stone,
Richard O. Francis,
Matthew S. Karafin

Affiliations

Shivang S. Shah: Department of Pediatrics, Columbia University, New York, NY, United States
Elizabeth F. Stone: Department of Pathology and Cell Biology, Columbia University, New York, NY, United States
Richard O. Francis: Department of Pathology and Cell Biology, Columbia University, New York, NY, United States
Matthew S. Karafin: Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, United States

DOI: https://doi.org/10.3389/fimmu.2024.1393213
Journal volume & issue: Vol. 15

Abstract

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. G6PD is an essential enzyme in the pentose phosphate pathway (PPP), generating NADPH needed for cellular biosynthesis and reactive oxygen species (ROS) homeostasis, the latter especially key in red blood cells (RBCs). Beyond the RBC, there is emerging evidence that G6PD exerts an immunologic role by virtue of its functions in leukocyte oxidative metabolism and anabolic synthesis necessary for immune effector function. We review these here, and consider the global immunometabolic role of G6PD activity and G6PD deficiency in modulating inflammation and immunopathology.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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