Nature Communications (Apr 2021)

Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway

  • Sitao Zhang,
  • Yongchang Xu,
  • Hongxin Guan,
  • Tao Cui,
  • Yuling Liao,
  • Wenhui Wei,
  • Jun Li,
  • Bachar H. Hassan,
  • Huimin Zhang,
  • Xu Jia,
  • Songying Ouyang,
  • Youjun Feng

DOI
https://doi.org/10.1038/s41467-021-22360-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present the Agrobacterium tumefaciens BioZ crystal structure.