Nature Communications (Apr 2021)
Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
Abstract
Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present the Agrobacterium tumefaciens BioZ crystal structure.