Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin‐induced ototoxicity
Yaqin Tu,
Guorun Fan,
Nan Wu,
Bo Liu,
Haiying Sun,
Qiong Wang,
Wenqing Zou,
Hongjun Xiao,
Songwei Tan
Affiliations
Yaqin Tu
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Guorun Fan
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Nan Wu
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Bo Liu
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Haiying Sun
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Qiong Wang
Cancer Center/Institute of Radiation Oncology/Hubei Key Laboratory of Precision Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Wenqing Zou
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Hongjun Xiao
Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Songwei Tan
School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
Abstract It is widely recognized that platinum‐based chemotherapy, particularly cisplatin therapy, can cause ototoxicity. At present, there are no Food and Drug Administration‐approved drugs to prevent or alleviate ototoxicity. Ototoxicity is generally believed to be caused by excessive reactive oxygen species production in the inner ear. Accordingly, a variety of antioxidants have been developed to protect against ototoxicity. To improve the efficiency of drug delivery to the cochlea, here, we synthesized simple and easy‐to‐obtain glutathione carbon dots (GSH CDs) with ultra‐small dimensions. The experimental results revealed that the GSH CDs have strong free‐radical scavenging activity and can restore mitochondrial function, maintain hair cell stability, and protect hair cells from cisplatin‐induced oxidative stress. Thus, GSH CDs may serve as a new therapeutic agent for preventing cisplatin‐induced ototoxicity.
