Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France; Corresponding author. Inserm U1235 Nantes, 1 rue Gaston Veil, Nantes 44035, France.
François Cossais
Department of Anatomy, Kiel University, Germany
Kristína Kulcsárová
Department of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Department of Neurology, L. Pasteur University Hospital, Kosice, Slovak Republic; Department of Clinical Neurosciences, University Scientific Park MEDIPARK, P. J. Safarik University, Kosice, Slovak Republic
Matej Škorvánek
Department of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Department of Neurology, L. Pasteur University Hospital, Kosice, Slovak Republic; Department of Clinical Neurosciences, University Scientific Park MEDIPARK, P. J. Safarik University, Kosice, Slovak Republic
Loïc Sellier-Montaigne
Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France
Emmanuel Coron
Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France
Laurène Leclair-Visonneau
Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France
Silvia Cerri
Unit of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation, Pavia 27100, Italy
Carolina Pellegrini
Unit of Histology and Embryology, Department of Clinical and Experimental Medicine, University of Pisa, Italy
Malvyne Rolli-Derkinderen
Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France
Summary: The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens. A compromised intestinal barrier has been reported in Parkinson’s disease (PD) further reinforcing the assumption that PD is a gut-brain axis disorder and suggesting that gut-derived factors may participate in disease development and/or progression. However, the diversity of methodology between existing studies on gut permeability in PD, especially regarding the methods used for the evaluation of the IEB, has led to diverging results and it is definitely too early to draw any definite conclusions. We envision novel approaches, such as intestinal organoids and confocal laser endomicroscopy that could be used to study more precisely the IEB in PD.
