Optimization of vasomotor and neuropsychiatric disorders treatment in climacteric syndrome

Abstract

The article presents data on a study of transdermal therapeutic system with 600 mkg ethinylestradiol and 6000 mkg norelgestromin, which was used for removal vasomotor and neuropsychiatric disorders of severe and middle course of climacteric syndrome. Purpose: to assess the effectiveness of influence of transdermal therapeutic system with 600 mkg ethinylestradiol and 6000 mkg norelgestromin for vasomotor and neuropsychiatric disorders of severe and middle climacteric syndrome. Materials and methods. 103 women of postmenopausal age with severe and middle climacteric disorders were under observation: 65 of them were included into the main group, 38 – the comparison group. Severity stage of climacteric manifestation was determined according to menopause rating scale (MRS) before treatment and a month after treatment. Women of the main group were offered to treat climacteric disorders with TTS, which contains 600 mkg ethinylestradiol and 6000 mkg norelgestromin, in regime 1 patch per 1 month. Traditional MHT preparation was prescribed to the women of the comparison group, this drug contains 1mg ethinylestradiol and 5 mg dydrohesteron, per os route in uninterrupted regime. Results. It was found reduction of vegetative, vascular and neuropsychiatric menopausal symptoms and total index of menopause from 25.9 ± 1.2 to 8.2 ± 0.9 – in the main group; and from 25.4 ± 1.6 to 9.9 ± 1.2 – in the comparison group. Reliable difference (p < 0.05) was found out after treatment between indexes of the main and comparison groups according to such criteria, as: hot flashes, sleeping disorders, joint and muscle complaints, depression, anxiety. These indexes were mush better in the main group. Conclusions. During treatment of severe and middle climacteric syndrome with TTS, which contains 600 mkg ethinylestradiol and 6000 mkg norelgestromin (Evra plaster), rapid and durable correction of vegetative, vascular and neuropsychiatric climacteric disorders was found out. Reliable reduction of total index of menopause in a month after treatment by 68.3 % from the first index (in the comparison group – 61 %) allows to recommend TTS with ethinylestradiol and norelgestromin as independent correction method for severe and middle climacteric disorders tratment. climacteric; psychoneuroses; ethinylestradiol; norelgestromin

Keywords

• climacteric
• psychoneuroses
• ethinylestradiol
• norelgestromin