Paediatrica Indonesiana (Aug 2007)
Effect of subdural hemorrhage on term infants development - a prospective study
Abstract
Background Subdural haemorrhage (SDH) is a common problem in infants under 6 months of age and it has a risk to develop into developmental delay. Objective To evaluate adverse effects of SDH on the development of term infants. Methods It was a prospective cohort study carried out on infants below six months of age admitted to Sanglah Hospital due to SDH. Control was healthy term infants born in Sanglah Hospital. Mullen Scales test was performed at the age of 6 and 12 months. Multivariate analysis was conducted to examine the relationship between several independent variabels and developmental outcome. Results Sixty six infants were enrolled in this study (33 infants with SDH and 33 infants without SDH), 52 (79%) were male and 14 (21%) were female. Mean age was 1.53 (SD 0.75) months vs 1.70 (SD 0.73) months. The result of Mullen Scales test at the age of 6 and 12 months showed that very low category was higher in infants with the history of SDH than that in control group. Multivariate logistic regression analysis showed that only SDH correlated with Gross Motor and Cognitive Scale delay at the age of 6 months and 12 months (Gross motor 6 months: P=0.01; OR 13.07; 95%CI 2.04;83.84; Gross motor 12 months: P=0.00; OR 23.58; 95%CI 2.87;193.84); (Cognitive 6 months: P=0.00; OR 12.11; 95%CI 2.44;59.90; Cognitive 12 months: P=0.00; OR 26.67; 95%CI 3.25;218.86). Conclusion Term infants with history of subdural haemorrhage are associated with increased Gross Motor and Cognitive Scale delay at the age of 6 and 12 months.
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