Data in support of toxicity studies of structurally modified plant virus to safety assessment
N.A. Nikitin,
V.A. Zenin,
E.A. Trifonova,
E.M. Ryabchevskaya,
M.S. Yurkova,
O.A. Kondakova,
A.N. Fedorov,
J.G. Atabekov,
O.V. Karpova
Affiliations
N.A. Nikitin
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation; Corresponding author.
V.A. Zenin
Group of Molecular Biotechnology, Federal State Institution “Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences”, 33-2 Leninsky pr., Moscow 119071, Russian Federation
E.A. Trifonova
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
E.M. Ryabchevskaya
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
M.S. Yurkova
Group of Molecular Biotechnology, Federal State Institution “Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences”, 33-2 Leninsky pr., Moscow 119071, Russian Federation
O.A. Kondakova
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
A.N. Fedorov
Group of Molecular Biotechnology, Federal State Institution “Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences”, 33-2 Leninsky pr., Moscow 119071, Russian Federation
J.G. Atabekov
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
O.V. Karpova
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation
This data article is related to the research article entitled “Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies” (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally denatured tobacco mosaic virus (TMV) coat protein and act as effective adjuvant for development of new vaccine candidates. This article reports the additional results on the toxicity studies of TMV SPs. The weight coefficients of laboratory animals internal organs complements the data of the subchronic toxicity studies. Also plaque-forming cell assay, delayed-type hypersensitivity test and peritoneal macrophage assay as a part of immunotoxicity studies of TMV SPs are presented. Keywords: Plant virus, Tobacco mosaic virus, Spherical particles, Toxicity
