Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats

Zhimin Miao; Shulai Lu; Na Du; Weiting Guo; Jidong Zhang; Yu Song; Xuefeng Wang; Wei Ren; Yunlong Wang; Tao Jiang

doi:10.1155/2012/459617

Mediators of Inflammation (Jan 2012)

Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats

Zhimin Miao,
Shulai Lu,
Na Du,
Weiting Guo,
Jidong Zhang,
Yu Song,
Xuefeng Wang,
Wei Ren,
Yunlong Wang,
Tao Jiang

Affiliations

Zhimin Miao: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China
Shulai Lu: Stomatological Department, Qingdao Municipal Hospital, Qingdao 266011, China
Na Du: Key Laboratory of Marine Drugs, School of Pharmacy, Ocean University of China, Ministry of Education of China, Qingdao 266003, China
Weiting Guo: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China
Jidong Zhang: Department of Cardiology, The Affiliated Hospital of Medical College Qingdao University, Qingdao 266011, China
Yu Song: Stomatological Department, Qingdao Municipal Hospital, Qingdao 266011, China
Xuefeng Wang: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China
Wei Ren: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China
Yunlong Wang: Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, China
Tao Jiang: Key Laboratory of Marine Drugs, School of Pharmacy, Ocean University of China, Ministry of Education of China, Qingdao 266003, China

DOI: https://doi.org/10.1155/2012/459617
Journal volume & issue: Vol. 2012

Abstract

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We have built a rat’s model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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