Nature Communications (Jul 2019)

An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

  • Y. Bill Kim,
  • Kevin T. Zhao,
  • David B. Thompson,
  • David R. Liu

DOI
https://doi.org/10.1038/s41467-019-10828-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.