精准医学杂志 (Feb 2023)

EFFECT OF DIFFERENT MAINTENANCE DOSES OF CAFFEINE CITRATE ON EARLY-STAGE PULMONARY FUNCTION AND COMPLICATIONS IN PRETERM INFANTS

  • GUO Yonglin, JIN Rong, WANG Qing, CUI Fengjing, LIU Dongyun

DOI
https://doi.org/10.13362/j.jpmed.202301003
Journal volume & issue
Vol. 38, no. 1
pp. 9 – 13

Abstract

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Objective To investigate the effect of different maintenance doses of caffeine citrate treatment on early-stage pulmonary function and complications in preterm infants. Methods A total of 78 preterm infants with a gestational age of 28 weeks to 33+6 weeks who were admitted to our hospital from April 2019 to January 2022 and did not need invasive mechanical ventilation after birth were enrolled as subjects, and they were divided into high-maintenance-dose caffeine citrate group with 40 infants and low-maintenance-dose caffeine citrate group with 38 infants using a random number table. Both groups were given peripheral intravenous pumping of caffeine citrate at a loading dose of 20 mg/(kg·d) at 2 h after birth, and then the high and low maintenance dose groups were given caffeine citrate at a maintenance dose of 10 mg/(kg·d) and 5 mg/(kg·d), respectively, after 24 h. The two groups were compared in terms of pulmonary function, complications (necrotizing enterocolitis, retinopathy of prematurity, and intraventricular hemorrhage), and adverse reactions (feeding intolerance, hyperglycemia, and tachycardia) on days 7 and 14 after birth and at the corrected gestational age of 40 weeks. Results Compared with the low maintenance dose group, the high maintenance dose group had significantly higher tidal volume, ratio of time to peak tidal expiratory flow to total expiratory time, and ratio of volume to peak tidal expiratory flow to total expiratory volume on days 7 and 14 after birth and at the corrected gestational age of 40 weeks, as well as a significantly higher respiratory rate on days 7 and 14 after birth (t=2.107-4.128,P<0.05). There were no significant differences in the incidence rates of complications and adverse reactions between the high and low maintenance dose groups (P>0.05). Conclusion A high maintenance dose of caffeine citrate can significantly improve early-stage pulmonary function in preterm infants without increasing related complications and adverse reactions.

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