Nature Communications (Dec 2020)
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
- Sara Campinoti,
- Asllan Gjinovci,
- Roberta Ragazzini,
- Luca Zanieri,
- Linda Ariza-McNaughton,
- Marco Catucci,
- Stefan Boeing,
- Jong-Eun Park,
- John C. Hutchinson,
- Miguel Muñoz-Ruiz,
- Pierluigi G. Manti,
- Gianluca Vozza,
- Carlo E. Villa,
- Demetra-Ellie Phylactopoulos,
- Constance Maurer,
- Giuseppe Testa,
- Hans J. Stauss,
- Sarah A. Teichmann,
- Neil J. Sebire,
- Adrian C. Hayday,
- Dominique Bonnet,
- Paola Bonfanti
Affiliations
- Sara Campinoti
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Asllan Gjinovci
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Roberta Ragazzini
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Luca Zanieri
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Linda Ariza-McNaughton
- Haematopoietic Stem Cell laboratory, The Francis Crick Institute
- Marco Catucci
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Stefan Boeing
- Bioinformatics Laboratory, The Francis Crick Institute
- Jong-Eun Park
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- John C. Hutchinson
- UCL Great Ormond Street Institute of Child Health
- Miguel Muñoz-Ruiz
- Immunosurveillance laboratory, The Francis Crick Institute
- Pierluigi G. Manti
- Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS
- Gianluca Vozza
- Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS
- Carlo E. Villa
- Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS
- Demetra-Ellie Phylactopoulos
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Constance Maurer
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- Giuseppe Testa
- Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS
- Hans J. Stauss
- Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital
- Sarah A. Teichmann
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Neil J. Sebire
- UCL Great Ormond Street Institute of Child Health
- Adrian C. Hayday
- Immunosurveillance laboratory, The Francis Crick Institute
- Dominique Bonnet
- Haematopoietic Stem Cell laboratory, The Francis Crick Institute
- Paola Bonfanti
- Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-020-20082-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tissue that supports mature T cell development in vitro and in vivo.
